Human VWF-A2/VWF ELISA Kit PicoKine® | Boster EK1743 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human VWF-A2/VWF ELISA Kit PicoKine®

catalog :

EK1743

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1743

Product Name :

Human VWF-A2/VWF ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human VWF-A2/VWF ELISA Kit PicoKine® (96 Tests). Quantitate Human VWF in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

VWF

Uniprot ID :

P04275

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: D1498-V1665

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A polyclonal antibody from sheep, a biotinylated detection polyclonal antibody from sheep

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

von Willebrand factor

Synonyms :

von Willebrand factor; vWF; von Willebrand antigen 2; von Willebrand antigen II; VWF; F8VWF

Protein Function :

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone f

Subcellular Localization :

Secreted, extracellular matrix

Tissue Specificity :

Plasma

Background :

Von Willebrand factor (VWF) is a blood glycoprotein involved in hemostasis. It is mapped to 12p13.31. The VWF gene encodes von Willebrand factor (VWF), a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of plateletvessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. VWF deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Invasion/Microenvironment, Platelets, Serum Proteins, Stem Cells