Rat SEMA3F/Semaphorin-3F ELISA Kit PicoKine® | Boster EK1735 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat SEMA3F/Semaphorin-3F ELISA Kit PicoKine®

catalog :

EK1735

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1735

Product Name :

Rat SEMA3F/Semaphorin-3F ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat SEMA3F ELISA Kit PicoKine® (96 Tests). Quantitate Rat SEMA3F in cell culture supernatants, serum and plasma (heparin, EDTA or citrate) . Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

Sema3f

Uniprot ID :

D3ZGX9

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A19-T785

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA or citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

semaphorin 3F

Synonyms :

Sema-3f; Sema3f

Protein Function :

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Subcellular Localization :

Cell membrane. Single-pass type I membrane protein.

Background :

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene. It is mapped to 8q32. The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues. Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G, chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones through an interaction with a collapsin response mediator protein of relative molecular mass 62K , a putative homolog of an axonal guidance associated UNC33 gene product. SEMA3F is a secreted member of the semaphorin III family.

Research Category :

Axonal Guidance Proteins, Growth And Development, Neurogenesis, Neurology Process, Neuroscience