Human AMICA/JAML ELISA Kit PicoKine® | Boster EK1730 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human AMICA/JAML ELISA Kit PicoKine®

catalog :

EK1730

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1730

Product Name :

Human AMICA/JAML ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human AMICA/JAML ELISA Kit PicoKine® (96 Tests). Quantitate Human JAML in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

JAML

Uniprot ID :

Q86YT9

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L20-L275

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

junction adhesion molecule like

Synonyms :

Junctional adhesion molecule-like; Adhesion molecule interacting with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; JAML; AMICA1; UNQ722; PRO1387

Protein Function :

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors me

Subcellular Localization :

Cell membrane, Single-pass type I membrane protein, Cell junction

Tissue Specificity :

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes.

Background :

JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member. This gene is mapped to 11q23.3. It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. A known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice) which has been shown to localize to the tight junctions of epithelial cells. JAML-mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models. Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.

Research Category :

Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton / Ecm, Immunology, Signal Transduction, Tight Junctions