Human HRG ELISA Kit PicoKine® | Boster EK1707 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human HRG ELISA Kit PicoKine®

catalog :

EK1707

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1707

Product Name :

Human HRG ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human HRG ELISA Kit PicoKine® (96 Tests). Quantitate Human HRG in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Human

Gene Name :

HRG

Uniprot ID :

Q6P1K1

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V19-K525

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

histidine rich glycoprotein

Synonyms :

Heme transporter HRG1; Heme-responsive gene 1 protein homolog; HRG-1; hHRG-1; Solute carrier family 48 member 1; SLC48A1; HRG1

Protein Function :

Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.

Subcellular Localization :

Endosome membrane

Tissue Specificity :

Highly expressed in the brain, kidney, heart and skeletal muscle. Moderately expressed in the liver, lung, placenta and small intestine.

Background :

HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

Research Category :

Cancer, Neural Signal Transduction, Neurology Process, Neuroscience