Rat PDGF-BB ELISA Kit PicoKine® | Boster EK1698 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat PDGF-BB ELISA Kit PicoKine®

catalog :

EK1698

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1698

Product Name :

Rat PDGF-BB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat PDGF-BB ELISA Kit PicoKine® (96 Tests). Quantitate Rat Tgfb1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Rat

Application :

ELISA

Gene Name :

Tgfb1

Uniprot ID :

Q62908

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S82-T190

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

transforming growth factor, beta 1

Synonyms :

Cysteine and glycine-rich protein 2; Cysteine-rich protein 2; CRP2; Smooth muscle cell LIM protein; SmLIM; Csrp2; Smlim

Protein Function :

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Subcellular Localization :

Nucleus.

Background :

PDGF-BB encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Research Category :

Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Metabolism, Metabolism Processes, Organogenesis, Pathways And Processes, Response To Hypoxia, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tgf Beta