Mouse PDGF-BB ELISA Kit PicoKine® | Boster EK1697 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse PDGF-BB ELISA Kit PicoKine®

catalog :

EK1697

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1697

Product Name :

Mouse PDGF-BB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse PDGF-BB ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Pdgfb in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Pdgfb

Uniprot ID :

Q9QXT5

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S82-T190

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

platelet derived growth factor, B polypeptide

Synonyms :

Epidermal growth factor-like protein 7; EGF-like protein 7; Multiple epidermal growth factor-like domains protein 7; Multiple EGF-like domains protein 7; NOTCH4-like protein; Vascular endothelial statin; VE-statin; Zneu1; Egfl7; Megf7

Protein Function :

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Subcellular Localization :

Secreted, extracellular space

Tissue Specificity :

Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney.

Background :

PDGF-BB encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Research Category :

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Growth Factors, Growth Factors/Hormones, Immunology, Metabolism, Metabolism Processes, Neurology Process, Neuroscience, Pathways And Processes, Platelets, Response To Hypoxia, Secreted Molecules, Serum Proteins, Signal Transduction, Vascular Inflammation