Human Pro-collagen I alpha 1/COL1A1 ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Pro-collagen I alpha 1/COL1A1 ELISA Kit PicoKine®

catalog :

EK1692

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1692

Product Name :

Human Pro-collagen I alpha 1/COL1A1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Pro-collagen I alpha 1/COL1A1 ELISA Kit PicoKine® (96 Tests). Quantitate Human COL1A1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml .

Reactivity :

Human

Application :

ELISA

Gene Name :

COL1A1

Uniprot ID :

P02452

Immunogen :

Expression system for standard: CHO; Immunogen sequence: Q23-K277 + G1094-L1464

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

collagen type I alpha 1 chain

Synonyms :

Collagen alpha-1 (I) chain; Alpha-1 type I collagen; COL1A1

Protein Function :

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subcellular Localization :

Secreted, extracellular space, extracellular matrix

Tissue Specificity :

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Background :

Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. And this gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.

Research Category :

Collagen, Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells