Human B2M / beta 2 Microglobulin ELISA Kit PicoKine® | Boster EK1691 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human B2M / beta 2 Microglobulin ELISA Kit PicoKine®

catalog :

EK1691

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1691

Product Name :

Human B2M / beta 2 Microglobulin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human B2M / beta 2 Microglobulin ELISA Kit PicoKine® (96 Tests). Quantitate Human B2M in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml .

Reactivity :

Human

Application :

ELISA

Gene Name :

B2M

Uniprot ID :

P61769

Immunogen :

Expression system for standard: from plasma

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

beta-2-microglobulin

Synonyms :

Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; B2M; CDABP0092; HDCMA22P

Protein Function :

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

Subcellular Localization :

Secreted.

Background :

Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Research Category :

Cancer, Cardiovascular, Serum Proteins, Tumor Biomarkers