Human ULBP3 ELISA Kit PicoKine® | Boster EK1686 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ULBP3 ELISA Kit PicoKine®

catalog :

EK1686

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1686

Product Name :

Human ULBP3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ULBP3 ELISA Kit PicoKine® (96 Tests). Quantitate Human ULBP3 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ULBP3

Uniprot ID :

Q9BZM4

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D30-G217

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

UL16 binding protein 3

Synonyms :

UL16-binding protein 3; ALCAN-gamma; NKG2D ligand 3; N2DL-3; NKG2DL3; Retinoic acid early transcript 1N; ULBP3; N2DL3; RAET1N

Protein Function :

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Subcellular Localization :

Cell membrane. GPI-anchor.

Background :

UL16 binding protein 3 (ULBP3) is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6. It is mapped to 6q25.1. ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics.