Human ULBP1 ELISA Kit PicoKine® | Boster EK1685 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ULBP1 ELISA Kit PicoKine®

catalog :

EK1685

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1685

Product Name :

Human ULBP1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ULBP1 ELISA Kit PicoKine® (96 Tests). Quantitate Human ULBP1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Human

Application :

ELISA

Gene Name :

ULBP1

Uniprot ID :

Q9BZM6

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G26-G216

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

UL16 binding protein 1

Synonyms :

UL16-binding protein 1; ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; Retinoic acid early transcript 1I; ULBP1; N2DL1; RAET1I

Protein Function :

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Subcellular Localization :

Cell membrane

Tissue Specificity :

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Background :

UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6. ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus. The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.

Research Category :

Immunology, Innate Immunity, Nk Cells, Tlr Signaling