Human Transthyretin / TTR / PreAlbumin ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Transthyretin / TTR / PreAlbumin ELISA Kit PicoKine®

catalog :

EK1684

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1684

Product Name :

Human Transthyretin / TTR / PreAlbumin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Transthyretin / TTR / PreAlbumin ELISA Kit PicoKine® (96 Tests). Quantitate Human TTR in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10 pg/ml .

Reactivity :

Human

Application :

ELISA

Gene Name :

TTR

Uniprot ID :

P02766

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G21-E147

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

transthyretin

Synonyms :

Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB

Protein Function :

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Subcellular Localization :

Secreted. Cytoplasm.

Tissue Specificity :

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Background :

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Research Category :

Alzheimer'S Disease, Cardiovascular, Neurodegenerative Disease, Neurology Process, Neuroscience, Serum Proteins