Human Cystatin SN/CST1 ELISA Kit PicoKine® | Boster EK1654 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cystatin SN/CST1 ELISA Kit PicoKine®

catalog :

EK1654

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1654

Product Name :

Human Cystatin SN/CST1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Cystatin SN/CST1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CST1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CST1

Uniprot ID :

P01037

Immunogen :

Expression system for standard: NS0; Immunogen sequence: W21-S141

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva and urine

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

cystatin SN

Synonyms :

Cystatin-SN; Cystain-SA-I; Cystatin-1; Salivary cystatin-SA-1; CST1

Protein Function :

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.

Background :

Cystatin-SN is a protein that in humans is encoded by the CST1 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.