Human VAP-1/AOC3 ELISA Kit PicoKine® | Boster EK1646 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human VAP-1/AOC3 ELISA Kit PicoKine®

catalog :

EK1646

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1646

Product Name :

Human VAP-1/AOC3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human VAP-1/AOC3 ELISA Kit PicoKine® (96 Tests). Quantitate Human AOC3 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

AOC3

Uniprot ID :

Q16853

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N2-N763

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

amine oxidase, copper containing 3

Synonyms :

Membrane primary amine oxidase

Protein Name :

Membrane primary amine oxidase

Protein Function :

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.

Subcellular Localization :

Cell membrane

Tissue Specificity :

Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.

Background :

Amine oxidase, copper containing 3, also known as vascular adhesion protein (VAP-1) and HPAO is an enzyme that in humans is encoded by the AOC3 gene on chromosome 17. This protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family and is associated with many vascular diseases. This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.

Research Category :

Alzheimer'S Disease, Cell Adhesion, Cell Adhesion Molecules, Cytoskeleton / Ecm, Neurodegenerative Disease, Neurology Process, Neuroscience, Signal Transduction