Human Dystroglycan ELISA Kit PicoKine® | Boster EK1614 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Dystroglycan ELISA Kit PicoKine®

catalog :

EK1614

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1614

Product Name :

Human Dystroglycan ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Dystroglycan ELISA Kit PicoKine® (96 Tests). Quantitate Human DAG1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

DAG1

Uniprot ID :

Q14118

Immunogen :

Expression system for standard: NS0; Immunogen sequence: H30-G653

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva and urine

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

dystroglycan 1

Synonyms :

Dystroglycan; Dystrophin-associated glycoprotein 1; Alpha-dystroglycan; Alpha-DG; Beta-dystroglycan; Beta-DG; DAG1;

Protein Function :

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.

Subcellular Localization :

Alpha-dystroglycan: Secreted, extracellular space.

Tissue Specificity :

Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.

Background :

Dystrophin, also known as DMD, is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. It is mapped to Xp21.2-p21.1. This complex is variously known as the costamere or thedystrophin-associated protein complex. Many muscle proteins, such as α-dystrobrevin, syncoilin, synemin, sarcoglycan, dystroglycan, and sarcospan, colocalize with dystrophin at the costamere. Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to another support protein that resides on the inside surface of each muscle fiber’s plasma membrane (sarcolemma).

Research Category :

Actin Binding Proteins, Actin Etc, Cytoskeleton, Cytoskeleton / Ecm, Microfilaments, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction