Human IL-23R/Interleukin-23 receptor ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-23R/Interleukin-23 receptor ELISA Kit PicoKine®

catalog :

EK1612

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1612

Product Name :

Human IL-23R/Interleukin-23 receptor ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-23R ELISA Kit PicoKine® (96 Tests). Quantitate Human IL23R in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL23R

Uniprot ID :

Q5VWK5

Immunogen :

Expression system for standard: NS0; Immunogen sequence: I25-I354

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

interleukin 23 receptor

Synonyms :

Interleukin-23 receptor; IL-23 receptor; IL-23R; IL23R;

Protein Function :

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Subcellular Localization :

Cell membrane

Tissue Specificity :

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Background :

Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Research Category :

Cell Type Markers, Cytokines, Epigenetics and Nuclear Signaling, Immunoglobulins, Immunology, Innate Immunity, Interleukins, Nuclear Signaling, Nuclear Signaling Pathways, Receptors, Signal Transduction, Signaling Pathway