Mouse BMP-9 ELISA Kit PicoKine® | Boster EK1610 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse BMP-9 ELISA Kit PicoKine®

catalog :

EK1610

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1610

Product Name :

Mouse BMP-9 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse BMP-9 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Gdf2 in bone tissue, cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Gdf2

Uniprot ID :

Q9WV56

Immunogen :

Expression system for standard: CHO; Immunogen sequence: S319-R428

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

bone tissue, cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

growth differentiation factor 2

Synonyms :

Growth/differentiation factor 2; GDF-2; Bone morphogenetic protein 9; BMP-9; Gdf2; Bmp9;

Protein Function :

Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.

Subcellular Localization :

Secreted.

Background :

Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton.

Research Category :

Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton / Ecm, Extracellular Matrix, Growth Factors/Hormones, Signal Transduction, Structures