Human ULBP2 ELISA Kit PicoKine® | Boster EK1593 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ULBP2 ELISA Kit PicoKine®

catalog :

EK1593

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1593

Product Name :

Human ULBP2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ULBP2 ELISA Kit PicoKine® (96 Tests). Quantitate Human ULBP2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ULBP2

Uniprot ID :

Q9BZM5

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G26-S216

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<12 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

NKG2D ligand 2

Synonyms :

NKG2D ligand 2;N2DL-2;NKG2DL2;ALCAN-alpha;Retinoic acid early transcript 1H;UL16-binding protein 2;ULBP2;N2DL2, RAET1H;UNQ463/PRO791;

Protein Name :

NKG2D ligand 2

Molecular Weight :

27368 MW

Protein Function :

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Subcellular Localization :

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Tissue Specificity :

Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.

Background :

UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells.

Research Category :

Immunology, Innate Immunity, Nk Cells, Tlr Signaling