Rat FGF23 ELISA Kit PicoKine® | Boster EK1591 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat FGF23 ELISA Kit PicoKine®

catalog :

EK1591

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1591

Product Name :

Rat FGF23 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat FGF23 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Fgf23 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Rat

Application :

ELISA

Gene Name :

Fgf23

Uniprot ID :

Q8VI82

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Y25-V251

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

fibroblast growth factor 23

Synonyms :

Fibroblast growth factor 23; FGF-23; Fgf23

Protein Function :

Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.

Subcellular Localization :

Secreted . Secretion is dependent on O-glycosylation.

Tissue Specificity :

Expressed in the parathyroid.

Background :

Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.

Research Category :

Lineage Specification, Signal Transduction, Stem Cells, Structures