Mouse EFEMP1 ELISA Kit PicoKine® | Boster EK1590 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse EFEMP1 ELISA Kit PicoKine®

catalog :

EK1590

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1590

Product Name :

Mouse EFEMP1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse EFEMP1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Efemp1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Efemp1

Uniprot ID :

Q8BPB5

Immunogen :

Expression system for standard: CHO; Immunogen sequence: Q18-F493

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

epidermal growth factor-containing fibulin-like extracellular matrix protein 1

Synonyms :

EGF-containing fibulin-like extracellular matrix protein 1; Fibulin-3; FIBL-3; Efemp1; Fbln3

Protein Function :

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity).

Subcellular Localization :

Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . Localizes to the lamina propria underneath the olfactory epithelium.

Background :

EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.

Research Category :

Calcium Binding Proteins, Calcium Signaling, Neuroscience, Sensory System, Signal Transduction, Signaling Pathway, Visual System