Human Siglec5/Cd170 ELISA Kit PicoKine® | Boster EK1583 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Siglec5/Cd170 ELISA Kit PicoKine®

catalog :

EK1583

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1583

Product Name :

Human Siglec5/Cd170 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Siglec5/Cd170 ELISA Kit PicoKine® (96 Tests). Quantitate Human SIGLEC5 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SIGLEC5

Uniprot ID :

O15389

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E17-L441

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Sialic acid-binding Ig-like lectin 5

Synonyms :

Sialic acid-binding Ig-like lectin 5;Siglec-5;CD33 antigen-like 2;Obesity-binding protein 2;OB-BP2;OB-binding protein 2;CD170;SIGLEC5;CD33L2, OBBP2;

Protein Name :

Sialic acid-binding Ig-like lectin 5

Molecular Weight :

60715 MW

Protein Function :

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Background :

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Research Category :

Cell Type Markers, Immunology