Human TNFRSF25/DR3 ELISA Kit PicoKine® | Boster EK1579 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF25/DR3 ELISA Kit PicoKine®

catalog :

EK1579

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1579

Product Name :

Human TNFRSF25/DR3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TNFRSF25/DR3 ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF25 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF25

Uniprot ID :

Q93038

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q25-F201

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 25

Synonyms :

Tumor necrosis factor receptor superfamily member 25;Apo-3;Apoptosis-inducing receptor AIR;Apoptosis-mediating receptor DR3;Apoptosis-mediating receptor TRAMP;Death receptor 3;Lymphocyte-associated receptor of death;LARD;Protein WSL;Protein WSL-1;TNFRSF25;APO3, DDR3, DR3, TNFRSF12, WSL, WSL1;UNQ455/PRO779;

Protein Name :

Tumor necrosis factor receptor superfamily member 25

Molecular Weight :

45385 MW

Protein Function :

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Tissue Specificity :

Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Background :

Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Research Category :

Apoptosis, Cell Biology, Nfkb Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway