Human CHL1/L1CAM-2 ELISA Kit PicoKine® | Boster EK1576 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CHL1/L1CAM-2 ELISA Kit PicoKine®

catalog :

EK1576

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1576

Product Name :

Human CHL1/L1CAM-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CHL1/L1CAM-2 ELISA Kit PicoKine® (96 Tests). Quantitate Human CHL1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CHL1

Uniprot ID :

O00533

Immunogen :

Expression system for standard: NS0; Immunogen sequence: I25-Q1096

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Neural cell adhesion molecule L1-like protein

Synonyms :

Neural cell adhesion molecule L1-like protein;Close homolog of L1;Processed neural cell adhesion molecule L1-like protein;CHL1;CALL;

Protein Name :

Neural cell adhesion molecule L1-like protein

Molecular Weight :

135071 MW

Protein Function :

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Soluble forms produced by cleavage/shedding also exist.

Tissue Specificity :

Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.

Background :

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. This protein is a member of the L1 gene family of neural cell adhesion molecules. By FISH, the CHL1 gene was mapped to chromosome 3p26.1. The protein however has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations. This protein may also play a role in the growth of certain cancers.

Research Category :

Actin Binding Proteins, Actin Etc, Cell Adhesion Proteins, Cytoskeleton, Cytoskeleton / Ecm, Ecm Proteins, Membrane Proteins, Microfilaments, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction