Human LDLR ELISA Kit PicoKine® | Boster EK1542 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human LDLR ELISA Kit PicoKine®

catalog :

EK1542

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1542

Product Name :

Human LDLR ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human LDLR ELISA Kit PicoKine® (96 Tests). Quantitate Human LDLR in cell culture supernatants, serum, plasma (heparin) and urine. Sensitivity: 12pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LDLR

Uniprot ID :

P01130

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A22-R788

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<12 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin) and urine

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Low-density lipoprotein receptor

Synonyms :

Low-density lipoprotein receptor;LDL receptor;LDLR;

Protein Name :

Low-density lipoprotein receptor

Molecular Weight :

95376 MW

Protein Function :

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.

Background :

The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Research Category :

Cardiovascular, Lipid Metabolism, Lipids / Lipoproteins, Metabolism, Signal Transduction