Human FOLR2/Beta Fr ELISA Kit PicoKine® | Boster EK1539 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human FOLR2/Beta Fr ELISA Kit PicoKine®

catalog :

EK1539

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1539

Product Name :

Human FOLR2/Beta Fr ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human FOLR2/Beta Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR2 in cell culture supernatants and serum. Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FOLR2

Uniprot ID :

P14207

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T17-N230

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Folate receptor beta

Synonyms :

Folate receptor beta;FR-beta;Folate receptor 2;Folate receptor, fetal/placental;Placental folate-binding protein;FBP;FOLR2;

Protein Name :

Folate receptor beta

Molecular Weight :

29280 MW

Protein Function :

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Subcellular Localization :

Cell membrane; Lipid-anchor, GPI-anchor. Secreted .

Tissue Specificity :

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.

Background :

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

Research Category :

Cancer, Cofactors, Vitamins / Minerals, Metabolism, Pathways And Processes, Signal Transduction, Vitamins / Minerals