Human Nectin-4/PVRL4 ELISA Kit PicoKine® | Boster EK1536 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Nectin-4/PVRL4 ELISA Kit PicoKine®

catalog :

EK1536

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1536

Product Name :

Human Nectin-4/PVRL4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Nectin-4/PVRL4 ELISA Kit PicoKine® (96 Tests). Quantitate Human NECTIN4 in cell culture supernatants, serum, plasma (heparin, EDTA) , cell lysates and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

NECTIN4

Uniprot ID :

Q96NY8

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G32-S349

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), cell lysates and urine

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Nectin-4

Synonyms :

Nectin-4;Ig superfamily receptor LNIR;Nectin cell adhesion molecule 4 ;Poliovirus receptor-related protein 4;Processed poliovirus receptor-related protein 4;NECTIN4 ;LNIR, PRR4, PVRL4;

Protein Name :

Nectin-4

Molecular Weight :

55454 MW

Protein Function :

Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Colocalizes with MLLT4 at cadherin-based adherens junctions (PubMed:11544254).

Tissue Specificity :

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

Background :

Nectin-4, also known as PVRL4, is an adhesion receptor of the immunoglobulin superfamily and functions in cell-cell adhesion. This gene is mapped to chromosome 1q23.3. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.