Human TREML1/Tlt 1 ELISA Kit PicoKine® | Boster EK1521 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TREML1/Tlt 1 ELISA Kit PicoKine®

catalog :

EK1521

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1521

Product Name :

Human TREML1/Tlt 1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TREML1/Tlt 1 ELISA Kit PicoKine® (96 Tests). Quantitate Human TREML1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TREML1

Uniprot ID :

Q86YW5

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q16-P162

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Trem-like transcript 1 protein

Synonyms :

Trem-like transcript 1 protein;TLT-1;Triggering receptor expressed on myeloid cells-like protein 1;TREML1;TLT1;UNQ1825/PRO3438;

Protein Name :

Trem-like transcript 1 protein

Molecular Weight :

32679 MW

Protein Function :

Cell surface receptor that may play a role in the innate and adaptive immune response.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).

Tissue Specificity :

Detected in platelets, monocytic leukemia and in T-cell leukemia.

Background :

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene. This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. This protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants.

Research Category :

Cardiovascular, Immunology, Innate Immunity, Macrophage / Inflamm., Platelets, Protein Phosphorylation, Signal Transduction