Human ALK-1/ACVRL1 ELISA Kit PicoKine® | Boster EK1518 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ALK-1/ACVRL1 ELISA Kit PicoKine®

catalog :

EK1518

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1518

Product Name :

Human ALK-1/ACVRL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ALK-1/ACVRL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human ACVRL1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ACVRL1

Uniprot ID :

P37023

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D22-Q118

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Serine/threonine-protein kinase receptor R3

Synonyms :

Serine/threonine-protein kinase receptor R3;SKR3;2.7.11.30;Activin receptor-like kinase 1;ALK-1;TGF-B superfamily receptor type I;TSR-I;ACVRL1;ACVRLK1, ALK1;

Protein Name :

Serine/threonine-protein kinase receptor R3

Molecular Weight :

56124 MW

Protein Function :

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Background :

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Research Category :

Amino Acid Metabolism, Amino Acids, Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction, Vasculature