Human alpha-defensin 1/DEFA1 ELISA Kit PicoKine® | Boster EK1514 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human alpha-defensin 1/DEFA1 ELISA Kit PicoKine®

catalog :

EK1514

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1514

Product Name :

Human alpha-defensin 1/DEFA1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human alpha-defensin 1/DEFA1 ELISA Kit PicoKine® (96 Tests). Quantitate Human DEFA1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

DEFA1

Uniprot ID :

P59665

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: D39-C94

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from sheep

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

defensin alpha 1

Synonyms :

Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; HP1; HP 1-56; Neutrophil defensin 2; HNP-2; HP-2; HP2; DEFA1; DEF1; DEFA2; MRS; DEFA1B

Protein Function :

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Subcellular Localization :

Secreted.

Background :

Defensin is a human protein that is encoded by the DEFA1 gene. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Research Category :

Defensin, Human Protein, Immunology, Innate Immunity, Macrophage / Inflamm., Microbiology, Protein, Secreted Molecules