Human DTK/TYRO3 ELISA Kit PicoKine® | Boster EK1496 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human DTK/TYRO3 ELISA Kit PicoKine®

catalog :

EK1496

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1496

Product Name :

Human DTK/TYRO3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human DTK/TYRO3 ELISA Kit PicoKine® (96 Tests). Quantitate Human TYRO3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TYRO3

Uniprot ID :

Q06418

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A41-S428

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tyrosine-protein kinase receptor TYRO3

Synonyms :

Tyrosine-protein kinase receptor TYRO3;2.7.10.1;Tyrosine-protein kinase BYK;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase TIF;TYRO3;BYK, DTK, RSE, SKY, TIF;

Protein Name :

Tyrosine-protein kinase receptor TYRO3

Molecular Weight :

96905 MW

Protein Function :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity :

Abundant in the brain and lower levels in other tissues.

Background :

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene. The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.

Research Category :

Cell Adhesion Proteins, Intracellular Signaling, Kinases, Membrane Proteins, Neuroscience, Neurotransmission, Protein Phosphorylation, Signal Transduction, Tyrosine Kinases