Human HE4 ELISA Kit PicoKine® | Boster EK1469 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human HE4 ELISA Kit PicoKine®

catalog :

EK1469

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1469

Product Name :

Human HE4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human HE4 ELISA Kit PicoKine® (96 Tests). Quantitate Human WFDC2 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

WFDC2

Uniprot ID :

Q14508

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: E31-F124

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from sheep

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

WAP four-disulfide core domain protein 2

Synonyms :

WAP four-disulfide core domain protein 2;Epididymal secretory protein E4;Major epididymis-specific protein E4;Putative protease inhibitor WAP5;WFDC2;HE4, WAP5;

Protein Name :

WAP four-disulfide core domain protein 2

Molecular Weight :

12993 MW

Protein Function :

Broad range protease inhibitor.

Subcellular Localization :

Secreted .

Tissue Specificity :

Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Background :

WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Research Category :

Tags & Cell Markers, Cell Type Markers, Tumor Associated