Human AGT/Serpin A8/Angiotensinogen ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human AGT/Serpin A8/Angiotensinogen ELISA Kit PicoKine®

catalog :

EK1465

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1465

Product Name :

Human AGT/Serpin A8/Angiotensinogen ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human AGT/Serpin A8/Angiotensinogen ELISA Kit PicoKine® (96 Tests). Quantitate Human AGT in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

AGT

Uniprot ID :

P01019

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D34-A485

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

angiotensinogen

Synonyms :

Angiotensinogen; Serpin A8; Angiotensin-1; Angiotensin 1-10; Angiotensin I; Ang I; Angiotensin-2; Angiotensin 1-8; Angiotensin II; Ang II; Angiotensin-3; Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II; Angiotensin-4; Angiotensin 3-8; Angiotensin IV; Ang IV; Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4; AGT; SERPINA8

Protein Function :

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed by the liver and secreted in plasma.

Background :

AGT (ANGIOTENSINOGEN), also called SERPINA8, is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. ATG is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Angiotensinogen is also known as renin substrate. The AGT gene is mapped on 1q42.2. And the human angiotensinogen gene contains 5 exons. The expression of AGT and enzymes required for its conversion to angiotensin II in human adipose tissue. Mutations in this AGT gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Research Category :

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway