Human APOE/Apolipoprotein E ELISA Kit PicoKine® | Boster EK1455 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human APOE/Apolipoprotein E ELISA Kit PicoKine®

catalog :

EK1455

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1455

Product Name :

Human APOE/Apolipoprotein E ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human APOE/Apolipoprotein E ELISA Kit PicoKine® (96 Tests). Quantitate Human APOE in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, milk and urine. Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

APOE

Uniprot ID :

P02649

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: K19-H317

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

3.12 ng/ml - 200 ng/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, milk and urine

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Apolipoprotein E

Synonyms :

Apolipoprotein E;Apo-E;APOE;

Protein Name :

Apolipoprotein E

Molecular Weight :

36154 MW

Protein Function :

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Subcellular Localization :

Secreted.

Tissue Specificity :

Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

Background :

Apolipoprotein E (APOE) is a class of apolipoprotein found in the chylomicron and Intermediate-density lipoprotein (IDLs) that is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. In peripheral tissues, APOE is primarily produced by the liver and macrophages, and mediates cholesterol metabolism in an isoform- dependent manner. In the central nervous system, APOE is mainly produced by astrocytes, and transports cholesterol to neurons via APOE receptors, which are members of the low density lipoprotein receptor gene family. This protein is involved in Alzheimer’s disease and cardiovascular disease.

Research Category :

Cardiovascular, Lipid Metabolism, Lipids / Lipoproteins, Metabolism, Signal Transduction