Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine® | Boster EK1452 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine®

catalog :

EK1452

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1452

Product Name :

Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine® (96 Tests). Quantitate Human IDS in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IDS

Uniprot ID :

P22304

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S26-P550

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Iduronate 2-sulfatase

Synonyms :

Iduronate 2-sulfatase;3.1.6.13;Alpha-L-iduronate sulfate sulfatase;Idursulfase;Iduronate 2-sulfatase 42 kDa chain;Iduronate 2-sulfatase 14 kDa chain;IDS;SIDS;

Protein Name :

Iduronate 2-sulfatase

Molecular Weight :

61873 MW

Protein Function :

Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Subcellular Localization :

Lysosome

Tissue Specificity :

Liver, kidney, lung, and placenta.

Background :

Iduronate 2-sulfatase (IDS) is a sulfatase enzyme associated with Hunter syndrome. It encodes a member of the sulfatase family of proteins. Iduronate 2-sulfatase is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.