Human PD-L2/B7-DC ELISA Kit PicoKine® | Boster EK1447 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PD-L2/B7-DC ELISA Kit PicoKine®

catalog :

EK1447

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1447

Product Name :

Human PD-L2/B7-DC ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PD-L2/B7-DC ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1LG2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PDCD1LG2

Uniprot ID :

Q9BQ51

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L20-T220

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<12 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

programmed cell death 1 ligand 2

Synonyms :

Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; CD273; PDCD1LG2; B7DC, CD273, PDCD1L2, PDL2;

Protein Function :

Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

Subcellular Localization :

Isoform 3: Secreted

Tissue Specificity :

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

Background :

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance.

Research Category :

Immunoglobulins, Immunology, Receptors