Human CD28 ELISA Kit PicoKine® | Boster EK1429 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD28 ELISA Kit PicoKine®

catalog :

EK1429

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1429

Product Name :

Human CD28 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CD28 ELISA Kit PicoKine® (96 Tests). Quantitate Human CD28 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD28

Uniprot ID :

P10747

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N19-P152

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<12 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

T-cell-specific surface glycoprotein CD28

Synonyms :

T-cell-specific surface glycoprotein CD28;TP44;CD28;CD28;

Protein Name :

T-cell-specific surface glycoprotein CD28

Molecular Weight :

25066 MW

Protein Function :

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed in T-cells and plasma cells, but not in less mature B-cells.

Background :

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co- stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). The CD28 gene is mapped to 2q33-q34. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.

Research Category :

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage