Human AGRP/ART/Agouti-related protein ELISA Kit PicoKine®

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human AGRP/ART/Agouti-related protein ELISA Kit PicoKine®

catalog :

EK1427

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1427

Product Name :

Human AGRP/ART/Agouti-related protein ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human AGRP/agouti-related ELISA Kit PicoKine® (96 Tests). Quantitate Human AGRP in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 4pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

AGRP

Uniprot ID :

O00253

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A21-T132

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<4 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Agouti-related protein

Synonyms :

Agouti-related protein;AGRP;AGRT, ART;

Protein Name :

Agouti-related protein

Molecular Weight :

14440 MW

Protein Function :

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Subcellular Localization :

Secreted . Golgi apparatus lumen .

Tissue Specificity :

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

Background :

Agouti-related protein, also called Agouti-related peptide (AgRP), is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesised in NPY-containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. In humans, the agouti-related peptide is encoded by the AGRP gene. AgRP is co-expressed with Neuropeptide Y and works by increasing appetite and decreasing metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators.

Research Category :

Calcium Signaling, Cancer, Cardiovascular, Endocrine System, Fatty Acid Oxidation, Fatty Acids, Lipid And Lipoprotein Metabolism, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurology Process, Neuroscience, Obesity, Pathways And Processes, Redox Metabolism, Signal Transduction, Signaling Pathway