Human CD47 ELISA Kit PicoKine® | Boster EK1421 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD47 ELISA Kit PicoKine®

catalog :

EK1421

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1421

Product Name :

Human CD47 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CD47 ELISA Kit PicoKine® (96 Tests). Quantitate Human CD47 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD47

Uniprot ID :

Q08722

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q19-P139

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Leukocyte surface antigen CD47

Synonyms :

Leukocyte surface antigen CD47;Antigenic surface determinant protein OA3;Integrin-associated protein;IAP;Protein MER6;CD47;CD47;MER6;

Protein Name :

Leukocyte surface antigen CD47

Molecular Weight :

35214 MW

Protein Function :

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Subcellular Localization :

Cell membrane ; Multi-pass membrane protein .

Tissue Specificity :

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Sequence Similarities :

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Background :

CD47 (Cluster of Differentiation 47), also known as integrin associated protein (IAP), is a transmembrane protein that in humans is encoded by the CD47 gene. It belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. Also CD47 is ubiquitously expressed in human cells and has found to be overexpressed in many different tumor cells.

Research Category :

Cancer, Cell Type Markers, Immunology, Tumor Immunology