Human COMT ELISA Kit PicoKine® | Boster EK1406 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human COMT ELISA Kit PicoKine®

catalog :

EK1406

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1406

Product Name :

Human COMT ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human COMT ELISA Kit PicoKine® (96 Tests). Quantitate Human COMT in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

COMT

Uniprot ID :

P21964

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G52-P271

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Catechol O-methyltransferase

Synonyms :

Catechol O-methyltransferase;2.1.1.6;COMT;

Protein Name :

Catechol O-methyltransferase

Molecular Weight :

30037 MW

Protein Function :

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Subcellular Localization :

Isoform Soluble: Cytoplasm.

Tissue Specificity :

Brain, liver, placenta, lymphocytes and erythrocytes.

Background :

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter (DAT), such as the prefrontal cortex. This process is supposed to take place in postsynaptic neurons, as, in general, COMT is located intracellularly in the central nervous system (CNS).

Research Category :

Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways And Processes, Signal Transduction