Human CD97/ADGRE5 ELISA Kit PicoKine® | Boster EK1402 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD97/ADGRE5 ELISA Kit PicoKine®

catalog :

EK1402

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1402

Product Name :

Human CD97/ADGRE5 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CD97/ADGRE5 ELISA Kit PicoKine® (96 Tests). Quantitate Human ADGRE5 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ADGRE5

Uniprot ID :

P48960

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q21-Q398

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

CD97 antigen

Synonyms :

CD97 antigen;Leukocyte antigen CD97;CD97;CD97 antigen subunit alpha;CD97 antigen subunit beta;CD97;

Protein Name :

CD97 antigen

Molecular Weight :

91869 MW

Protein Function :

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).

Subcellular Localization :

Cell membrane; Multi-pass membrane protein.

Tissue Specificity :

Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.

Background :

Cluster of differentiation 97 is a protein also known as BL-Ac [F2] encoded by the ADGRE5 gene. The CD97 gene is mapped to 19p13.2-p13.12 by fluorescence in situ hybridization. In the immune system, CD97 is known as a critical mediator of host defense. Upon lymphoid, myeloid cells and neutrophil activation, CD97 is upregulated to promote adhesion and migration to sites of inflammation. Moreover, it has been shown that CD97 regulates granulocyte homeostasis. CD97 is expressed at the sarcoplasmic reticulum and the peripheral sarcolemma in skeletal muscle. However, lack of CD97 only affects the structure of the sarcoplasmic reticulum, but not the function of skeletal muscle.

Research Category :

Cell Type Markers, G Protein Signaling, Hematopoietic Progenitors, Immunology, More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway, Stem Cells