Human Complement Factor H/CFH ELISA Kit PicoKine® | Boster EK1399 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Complement Factor H/CFH ELISA Kit PicoKine®

catalog :

EK1399

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1399

Product Name :

Human Complement Factor H/CFH ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Complement Factor H/CFH ELISA Kit PicoKine® (96 Tests). Quantitate Human CFH in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CFH

Uniprot ID :

P08603

Immunogen :

Expression system for standard: from human plasma; Immunogen sequence: S860-R1231

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

1.56 ng/ml - 100 ng/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, monoclonal antibody from mouse

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Complement factor H

Synonyms :

Complement factor H;H factor 1;CFH;HF, HF1, HF2;

Protein Name :

Complement factor H

Molecular Weight :

139096 MW

Protein Function :

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed by the liver and secreted in plasma.

Background :

Complement factor H (CFH), originally known as beta-1H globulin, is a serum glycoprotein that regulates the function of the alternativecomplement pathway in fluid phase and on cellular surfaces. It binds to C3b, accelerates the decay of the alternative pathway convertase C3bBb, and also acts as a cofactor for complement factor I, another C3b inhibitor. The CFH gene is located on chromosome 1q32-q32.1 within a cluster of genes encoding the regulatory complement components of the activation of C3 (RCA for 'regulators of complement activation'). This gene cluster includes decay-accelerating factor (DAF), C4-binding protein (C4BPA and C4BPB), and the factor H-related genes CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5, among others. The gene family has arisen by multiple duplication events.