Human ERBB3/Her3 ELISA Kit PicoKine® | Boster EK1398 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ERBB3/Her3 ELISA Kit PicoKine®

catalog :

EK1398

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1398

Product Name :

Human ERBB3/Her3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ERBB3/Her3 ELISA Kit PicoKine® (96 Tests). Quantitate Human ERBB3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ERBB3

Uniprot ID :

P21860

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S20-T643

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Receptor tyrosine-protein kinase erbB-3

Synonyms :

Receptor tyrosine-protein kinase erbB-3;2.7.10.1;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3;ERBB3;HER3;

Protein Name :

Receptor tyrosine-protein kinase erbB-3

Molecular Weight :

148098 MW

Protein Function :

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Tissue Specificity :

Epithelial tissues and brain.

Background :

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. ErbB3 can heterodimerize with any of the other three ErbB family members. The theoretical ErbB3 homodimer would be non-functional because the kinase-impaired protein requires transphosporylation by its binding partner to be active. Unlike the other ErbB receptor tyrosine kinase family members which are activated through autophosphorylation upon ligand binding, ErbB3 is found to be kinase impaired, having only 1/1000th the autophosphorylation activity of EGFR and no ability to phosphorylate other proteins. Therefore, ErbB3 must act as anallosteric activator.

Research Category :

Apoptosis, Cell Biology, Developmental Biology, Growth Factors/Hormones, Intracellular, Kinases, Nervous System Development, Organogenesis, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases