Human Epiregulin ELISA Kit PicoKine® | Boster EK1394 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Epiregulin ELISA Kit PicoKine®

catalog :

EK1394

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1394

Product Name :

Human Epiregulin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Epiregulin ELISA Kit PicoKine® (96 Tests). Quantitate Human EREG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

EREG

Uniprot ID :

O14944

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: V60-L108

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

3.9 pg/ml - 250 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Proepiregulin

Synonyms :

Proepiregulin;Epiregulin;EPR;EREG;

Protein Name :

Proepiregulin

Molecular Weight :

19044 MW

Protein Function :

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).

Subcellular Localization :

Epiregulin: Secreted, extracellular space .

Tissue Specificity :

In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.

Background :

Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. It is a member of the epidermal growth factor family. Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.

Research Category :

Cancer, Growth Factors/Hormones, Signal Transduction, Tumor Biomarkers