Human Serpin C1/Antithrombin-III ELISA Kit PicoKine® | Boster EK1393 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Serpin C1/Antithrombin-III ELISA Kit PicoKine®

catalog :

EK1393

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1393

Product Name :

Human Serpin C1/Antithrombin-III ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Serpin C1/Antithrombin-III ELISA Kit PicoKine® (96 Tests). Quantitate Human SERPINC1 in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SERPINC1

Uniprot ID :

P01008

Immunogen :

Expression system for standard: NS0; Immunogen sequence: H33-K464

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Antithrombin-III

Synonyms :

Antithrombin-III;ATIII;Serpin C1;SERPINC1;AT3;PRO0309;

Protein Name :

Antithrombin-III

Molecular Weight :

52602 MW

Protein Function :

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular Localization :

Secreted, extracellular space.

Tissue Specificity :

Found in plasma.

Background :

Antithrombin III is the most important inhibitor of thrombin and other coagulation proteinases. It belongs to the serine proteinase inhibitor (serpin) superfamily of inhibitors and structurally related proteins, which contain reactive centers that have evolved to attract and entrap certain proteinases. Inherited antithrombin III deficiency (AT3D) is a risk factor for the early development of venous thromboembolism (THPH7). Antithrombin III regulates clot formation both by inhibiting thrombin activity directly and by interfering with earlier stages of the clotting cascade. By in situ hybridization and quantitative analysis of DNA dosage in carriers of chromosome 1 deletions, AT3 is mapped to 1q23-q25. The AT3 gene has 7 exons. It contains 9 complete and 1 partial repetitive ALU sequence elements, which occur in the introns of the gene at a higher frequency (about 22% of the intron sequence) than in the genome as a whole (about 5%).

Research Category :

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis / Ubiquitin