Human TGFBR3/Tgf Beta Riii ELISA Kit PicoKine® | Boster EK1383 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TGFBR3/Tgf Beta Riii ELISA Kit PicoKine®

catalog :

EK1383

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1383

Product Name :

Human TGFBR3/Tgf Beta Riii ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TGFBR3/Tgf Beta Riii ELISA Kit PicoKine® (96 Tests). Quantitate Human TGFBR3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TGFBR3

Uniprot ID :

Q03167

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G21-D781

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Transforming growth factor beta receptor type 3

Synonyms :

Transforming growth factor beta receptor type 3;TGF-beta receptor type 3;TGFR-3;Betaglycan;Transforming growth factor beta receptor III;TGF-beta receptor type III;TGFBR3;

Protein Name :

Transforming growth factor beta receptor type 3

Molecular Weight :

93499 MW

Protein Function :

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Subcellular Localization :

Secreted. Secreted, extracellular space. Cell membrane ; Single-pass type I membrane protein . Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Background :

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell- surfacechondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. By cDNA array and immunohistochemistry analyses, it is found that TGFBR3 expression is lost in most breast cancers examined in association with loss of heterozygosity of the TGFBR3 locus. TGFBR3 expression decreased during breast cancer progression, and low levels predicted decreased recurrence-free survival in patients. Loss of TGFBR3 through allelic imbalance is a frequent genetic event during breast cancer development that increases metastatic potential. Also, TGFBR3 can localize transformation in the heart and play an essential, nonredundant role in TGF-beta signaling.

Research Category :

Cytokines, Immunology, Innate Immunity, Signaling Pathways, Stem Cells, Surface Molecules, Tgf Beta