Mouse FGF21 ELISA Kit PicoKine® | Boster EK1379 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse FGF21 ELISA Kit PicoKine®

catalog :

EK1379

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1379

Product Name :

Mouse FGF21 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse FGF21 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Fgf21 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Fgf21

Uniprot ID :

Q9JJN1

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A29-S210

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Fibroblast growth factor 21

Synonyms :

Fibroblast growth factor 21;FGF-21;Fgf21;

Protein Name :

Fibroblast growth factor 21

Molecular Weight :

23237 MW

Protein Function :

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB.

Subcellular Localization :

Secreted .

Tissue Specificity :

Most abundantly expressed in the liver, also expressed in the thymus at lower levels.

Background :

Fibroblast growth factor 21 is a protein that in humans is encoded by the FGF21 gene. By genomic sequence analysis, Nishimura et al. (2000) identified the FGF21 gene within the 5-prime flanking region of the FUT1 gene on chromosome 19. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Signal Transduction