Human ADAMTS4 ELISA Kit PicoKine® | Boster EK1372 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ADAMTS4 ELISA Kit PicoKine®

catalog :

EK1372

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Zha Y, Chen Y, Xu F, Zhang J, Li T, Zhao C, et al. Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. Clin Res Cardiol. 2010;99:781-6 pubmed publisher

image

image 1 :

Human ADAMTS4 PicoKine ELISA Kit standard curve

product information

SKU :

EK1372

Product Name :

Human ADAMTS4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human ADAMTS4 ELISA Kit PicoKine® (96 Tests). Quantitate Human ADAMTS4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ADAMTS4

Uniprot ID :

O75173

Immunogen :

Expression system for standard: CHO; Immunogen sequence: F213-C685

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

625 pg/ml - 40,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

A disintegrin and metalloproteinase with thrombospondin motifs 4

Synonyms :

A disintegrin and metalloproteinase with thrombospondin motifs 4;ADAM-TS 4;ADAM-TS4;ADAMTS-4;3.4.24.82;ADMP-1;Aggrecanase-1;ADAMTS4;KIAA0688;UNQ769/PRO1563;

Protein Name :

A disintegrin and metalloproteinase with thrombospondin motifs 4

Molecular Weight :

90197 MW

Protein Function :

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu- -Ala-393' site.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix .

Tissue Specificity :

Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium.

Sequence Similarities :

Contains 1 disintegrin domain.

Background :

ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Research Category :

Cancer, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction

more info or order :

Boster product webpage