Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine® | Boster EK1370 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine®

catalog :

EK1370

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Chen W, Sun C, Chen S, Meynard D, Babitt J, Lin H. A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum. Haematologica. 2013;98:296-304 pubmed publisher

product information

SKU :

EK1370

Product Name :

Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Hjv in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

HFE2

Uniprot ID :

Q7TQ32

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q33-D393

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Hemojuvelin

Synonyms :

Hemojuvelin;Hemochromatosis type 2 protein homolog;RGM domain family member C;Hfe2;Rgmc;

Protein Name :

Hemojuvelin

Molecular Weight :

44848 MW

Protein Function :

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Subcellular Localization :

Cell membrane ; Lipid-anchor, GPI-anchor . Also released in the extracellular space.

Tissue Specificity :

Muscle cell lineage.

Background :

Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.

more info or order :

Boster product webpage