Mouse IL-34/Interleukin-34 ELISA Kit PicoKine® | Boster EK1366 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL-34/Interleukin-34 ELISA Kit PicoKine®

catalog :

EK1366

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1366

Product Name :

Mouse IL-34/Interleukin-34 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL-34 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il34 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

IL34

Uniprot ID :

Q8R1R4

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: N21-P235

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-34

Synonyms :

Interleukin-34;IL-34;Il34;

Protein Name :

Interleukin-34

Molecular Weight :

26764 MW

Protein Function :

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).

Subcellular Localization :

Secreted .

Background :

Interleukin-34, or IL-34 is a protein belonging to a group of cytokines called interleukins. It is mapped to 16q22.1. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. IL-34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF-1, CSF-1R. It also can promote the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor. In addition, it promotes the development, survival, and function of microglia and Langerhans cells, therefore, this cytokine may predominately function in brain and skin biology.

Research Category :

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage / Inflamm.