Mouse IL-24/Interleukin-24 ELISA Kit PicoKine® | Boster EK1359 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL-24/Interleukin-24 ELISA Kit PicoKine®

catalog :

EK1359

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1359

Product Name :

Mouse IL-24/Interleukin-24 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL-24 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il24 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Il24

Uniprot ID :

Q925S4

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Q27-L181

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

interleukin 24

Synonyms :

Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein; IL24; MDA7; ST16

Protein Function :

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Subcellular Localization :

Secreted .

Tissue Specificity :

Up-regulated in melanoma cells induced to terminally differentiate.

Background :

Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. By radiation hybrid analysis, the MDA7 gene is mapped to 1q32.2-q41. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. Mouse IL24 was expressed as an approximately 35-kD protein that was converted to a 23-kD protein by deglycosylation. The IL24 protein shares 24 to 33% homology with other members of the IL10 family of cytokines, with highest homology with IL20. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.

Research Category :

Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology