Human TFPI2 ELISA Kit PicoKine® | Boster EK1358 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TFPI2 ELISA Kit PicoKine®

catalog :

EK1358

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1358

Product Name :

Human TFPI2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TFPI2 ELISA Kit PicoKine® (96 Tests). Quantitate Human TFPI2 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TFPI2

Uniprot ID :

P48307

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D23-F235

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tissue factor pathway inhibitor 2

Synonyms :

Tissue factor pathway inhibitor 2;TFPI-2;Placental protein 5;PP5;TFPI2;

Protein Name :

Tissue factor pathway inhibitor 2

Molecular Weight :

26934 MW

Protein Function :

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Subcellular Localization :

Secreted.

Tissue Specificity :

Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Background :

TFPI2, also called Tissue factor pathway inhibitor 2, is a protein that in humans is encoded by the TFPI2 gene. It is mapped to 7q21.3. This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Qualitative PCR and microarray analyses showed that expression of TFPI2 was inversely correlated with that of MIR616 in prostate cancer cell lines, primary tumors of various grades, and normal tissue.

Research Category :

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis / Ubiquitin